AgroPages-Pesticides Registered & Launched in 2017 and Analysis of Key Products-Agricultural news

Paul Zheng

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Nowadays it takes roughly 11 years beginning from research and development of a novel active ingredient up to release of pesticide to market, at a cost of $286 million, which is 55 percent higher versus 10 years ago. Research and development of novel active ingredients are getting more difficult, which is well recognized among the industry beyond dispute. In 2017, all prime agrochemical enterprises have registered or launched a number of novel pesticide products in the world. However an awkward situation is that there have been few registrations or launches of novel active ingredients of pesticide in 2017. This article makes a summary of pesticides newly registered or launched in 2017 while giving highlight on the several novel active ingredients registered or launched in the year.

Tioxazafen

On the 1st May 2017, registration of Monsanto’s seed treatment nematicide NemaStrikeTM was approved by the U.S. EPA, having become an integral part of Monsanto’s Acceleron® Seed Applied Solutions. As known to all, compared with Syngenta, DowDupont and Bayer CropScience, Monsanto has not made big moves concerning novel pesticide development. In early 2017, Monsanto announced more than 20 research achievements over 4 consecutive years, where 14 products are about to be commercialized, which have included tioxazafen, the active ingredient of NemaStrike.

Tioxazafen is a broad-spectrum and systemic seed treatment nematicide developed by Monsanto in 2013, being a di-substituted oxadiazole. The new structure gives tioxazafen a new action mechanism, where the difference from other nematicides available on the market is that tioxazafen acts via interference with nematode ribosome. Hence, there is no cross resistance to other nematicides.

Tioxazafen is presently registered for application on corn, soybean and cotton for control of plant pathogenic nematode, such as cyst nematode, root-knot nematode, reniform nematode, root lesion nematode and longidorus. It’s application to vegetable is still under the way. Over the last 3 years Monsanto has conducted large amount of tioxazafen-oriented field trial and green house experiments, the results show that the control effect of tioxazafen as applied to various crops is equivalent or superior to the already commercialized products. Furthermore, it increases yield of corn, soybean and cotton.

The excellent control effect of tioxazafen originates from its distinctive control function, which is different from the inhibiting function of other nematicides. Nematode has a life cycle of about 30 days, tioxazafen SC has a low water solubility and can remain at around plant root system for a prolonged period, thus to provide a 75-day long lasting effect, which is 2.5 times of the life cycle of nematode.

It is worthy of note that tioxazafen is on;y registered for use in a production facility with full-automatic seed treatment equipment, where sealed conveyor and application device are used. Its use for on-site seed treatment is prohibited.

In September 2017, Monsanto announced release of NemaStrike to Brazilian market. As a novel active ingredient, tioxazafen enjoys 10-year registration protection rights, to be valid until 30th April 2027.

Florpyrauxifen

On the 31st August 2017, Dow AgroSciences obtained registration with China’s ICAMA of its herbicide florpyrauxifen 91.4% TC and florpyrauxifen 3% EC (trade name Rinskor®), this is the world’s first-time registration of florpyrauxifen. On the 15th September 2017, the florpyrauxifen-containing herbicide Loyant of Dow AgroSciences was also approved in U.S..

Florpyrauxifen is a novel aryl picolinate herbicide developed by Dow AgroSciences most recently and is a patent product of Dow AgroSciences, it is the second aryl picolinate herbicide following the halauxifen-methyl Arylex™. The trade names of the product include Rinskor® and Loyant®. Florpyrauxifen and halauxifen-methyl are both synthetic auxin herbicide with same action mechanism, acting via interference with the physiological and biochemical function of plant through in vivo hormone receptor binding, thus to cause the death of sensitive plant. However, a difference exists on the molecular structure of the two products, their target and herbicidal activity are different. Florpyrauxifen is mainly used for control of annual weed in rice field while halauxifen-methyl is mainly used for control of broad-leaf weed in grain crop field.

Florpyrauxifen has the advantages of broad spectrum, high efficiency, fast action and lower dosage, it can be applied to direct seeding rice, transplanted rice and the rest of crop field for post-emergence foliar treatment and for control of grassy weed, broad-leaf weed and nutgrass flatsedge. Because of its distinctive action mechanism, it can be used for weed resistance management for control of weeds resistant to ALS, ACCase, HPPD inhibitors, propanil, quinclorac, glyphosate and triazine herbicides. Moreover, the product is active on resistant barnyard grass in rice field due to its stable herbicidal property even under different conditions and water situations. Florpyrauxifen has a unique selectivity, which can be used safely to paddy rice and other crop fields.

According to Dow AgroSciences, the annual sales of florpyrauxifen is expected to reach over $200 million and total sales are likely to reach $2 billion. In 2017, there have been a lot of publicity and advertising on the florpyrauxifen-based herbicide Rinskor, which is expected to be launched to Chinese market in 2018 and to become an important substitute for penoxsulam.

Pydiflumetofen

In November 2017, Syngenta released to Argentina its fungicide MIRAVIS® Duo containing Syngenta’s latest active ingredient pydiflumetofen, which is the first-time release in the world.

Pydiflumetofen (trade name Adepidyn) is Syngenta’s latest pyrazole-carboxamide fungicide, it is a most recent SDHI fungicide masterpiece of Syngenta following its releases of Isopyrazam in 2010, sedaxane in 2011 and benzoenoxazole in 2012. Under the circumstance of global agrochemical downturn over recent years, SDHI fungicides have increased 15 percent on a yearly basis, becoming a dark horse in agrochemical market.

Being the first new member of chemical group of anthranilic diamides, the release of pydiflumetofen stands for Syngenta’s latest innovation in disease control. Pydiflumetofen is registered mainly for application to small grain crops, corn, soybean and special vegetable for control of gray mold, brown spot and stalk break. According to Syngenta, among the chemical group, pydiflumetofen has the highest activity on leaf spot disease and powdery mildew. It has also been a breakthrough in control of fusarium-caused disease on grain crops, such as fusarium head blight.

In November 2016, registration of Syngenta’s MIRAVIS® Duo was approved in Argentina. Syngenta has filed an application for registration of pydiflumetofen in the US, which is currently under review and expected to be approved in 2018. The sales of the product in the US will be in the trade name Miravis™. Syngenta predicts an annual sales of pydiflumetofen to reach a peak value of $750 million, which will become a SDHI fungicide with the highest market potential.

Picarbutrazox

In November 2017, Nippon Soda obtained approval in Japan of registration of its two fungicides - Nae Fine Flowable and Pisi Rock Flowable, both containing the novel active ingredient picarbutrazox. Nae Fine Flowable is used for control of rice breeding disease and seedling wilt while Pisi Rock Flowable is mainly used for control of vegetable oomycetes disease.

Picarbutrazox is a carbamate fungicide invented by Dainippon Ink and Chemicals (acquired by Nippon Soda in April 2004) and developed by Nippon Soda. The product was launched by Nippon Soda in 2013 and a provisional common name was ISO approved in the same year.

Due to the brand-new chemical structure, picarbutrazox possesses a brand-new action mechanism without cross resistance to other fungicides, being an excellent rotational-use spraying product. Picarbutrazox is mainly used for control of oomycetes diseases on melon vegetable, grain crop, tomato, potato, lawn, lettuce and leaf vegetable such as disc peronospora, pythium, peronospora and pseudoperonospora diseases.

Picarbutrazox is currently only registered and launched in Japan. According to the recent active ingredient list announced by U.S.EPA intended for registration in 2019, picarbutrazox is expected to be approved on the 17th April 2019 for application to leaf vegetable, melon vegetable, lawn, corn and soybean seed treatment.

Besides the above 4 kinds of novel active ingredients, a number of novel biopesticide have been registered or launched in global market in 2017, including the most representational biofungicide Serifel of BASF which is launched to the US market and the biofungicide Stargus of Marrone Bio Innovations as registered in the US. Serifel is BASF’s first patented biofungicide, with active ingredient being bacillus amyloiquefaciens strain MBI 600. The launch of Serifel marks an important step of the chemical giant BASF toward biological pesticide industry. The active ingredient of Stargus is also a kind of bacillus amyloliquefaciens, which is however a new strain discovered by Marrone Bio Innovations, for control of downy mildew, stalk break, botrytis and fruit rot. It is an important strategic product variety of Marrone Bio Innovations.

Though development of novel active ingredients are getting more difficult, what is encouraging is that many companies never stop their effort on research and development of novel pesticide. In the years ahead, a number of novel active ingredients are expected to emerge, which will include the grain crop fungicide fenpicoxamid, a latest development of Dow AgroSciences, the SDHI fungicide pyraziflumid of Nihon Nohyaku and the diamide insecticide tetraniliprole of Bayer CropScience.

Pesticides registered or launched in 2017

Company	Trade name	Active ingredient	Use	Status
Herbicides
Syngenta	Lumax	S-metolachlor+Mesotrione+ Terbuthylazine	Corn	Launched in Spain
Bayer CropScience	Provence Total	Indaziflam +Isoxaflutole	Sugarcane	Registered in Brazil
BASF	Zidua SC	Pyroxasulfone	Corn,soybean and wheat	Launched in USA
BASF	Atectra BV	Dicamba	Corn,wheat,sorghum and sugarcane	Launched in Argentina
Dow AgroSciences	Enlist One	2,4-D	Cotton,corn and soybean	Launched in USA
	Enlist Duo	2,4-D + Glyphosate	GM corn and soybean	Registered in Brazil
	Loyant	Rinskor	Rice	Registered in USA
Dupont	EverpreX	S-metolachlor	Soybean	Launched in North America
Dupont	Destra IS	Rimsulfuron+Mesotrione	Corn	Registered in Canada
Monsanto	Harness MAX	Acetochlor+ Mesotrione	Corn	Registered in USA
Arysta Life Science	EVEREST 3.0	Flucarbazone-sodium	Wheat	Launched in North America
Nufarm	Grapple	Rimsulfuron	Grape	Launched in USA
Nufarm	Gesaprim 500 CG	Atrazine	Sugarcane,corn and sorghum	Launched in Brazil
FMC	Battle Delta	Flufenacet+Diflufenican	Cereal	Launched in Italy
UPL	Fascinate	Glufosinate	Soybean,corn,cotton and kidney beans	Registered in Brazil
AMVAC	ImpactZ	Topramezone+Atrazine	Corn	Registered in USA
Gowan	Avanza 400 SC	Benzobicylon	Rice	Registered in Columbia
Gowan	Gambit	Halosulfuron+Prosulfuron	Rice	Registered in USA
Summit Agro USA	SHIELDEX 400SC	Tolpyralate	Corn	Registered in USA
Iharabras S/A Indústrias Químicas	TARGA MAX	Quizalofop-p-ethyl	Soybean	Launched in Brazil
Fungicides
Syngenta	MIRAVIS Duo	Pydiflumetofen + Difenoconazole	Peanut	Launched in Argentina
	Instrata Elite	Difenoconazole+Fludioxonil	Turf	Launched in UK
	Coratop Mametsubu	Pyroquilon	Rice	Launched in Japan
	Elatus Era	Benzovindiflupyr+Prothioconazole	Cereal	Registered in Ireland
	Aprovia Top	Difenoconazole+Benzovindiflupyr	Potato	Launched in Canada
	Revus Top	Mandipropamid+Difenoconazole	Potato	Launched in Argentina
Bayer CropScience	Prosaro XTR	Prothioconazole+Tebuconazole	Cereal	Launched in Canada
	Luna Tranquility	Fluopyram+Pyrimethanil	Fruits	Launched in Chile
	FOX Xpro	Trifloxystrobin + Prothioconazole	Soybean	Launched in Brazil
	Cropton Xpro	Bixafen + Prothioconazole + Trifloxystrobin	Wheat and barley	Launched in Argentina
	Exteris Stressgard	Fluopyram+Trifloxystrobin	Turf	Launched in UK
BASF	Pageant TR Intrinsic	Boscalid+Pyraclostrobin	ornamentals	Launched in USA
	Futura	Dithianon+Potassium phosphonate	Potato	Registered in France
	Vivando	Metrafenone	Mushroom	Launched in UK
	Sercadis	Fluxapyroxad	Potato	Launched in France
	Enervin Top	Ametoctradin+Thioneb	Grape	Launched in Spain
	Vision Plus	Pyrimethanil+Dithianon	Pome fruits	Launched in Spain
Arysta Life Science	Kaligreen	Potassium bicarbonate	Apple	Launched in Brazil
ADAMA	Cronnos	Mancozeb+Picoxystrobin+Tebuconazole	Soybean	Launched in Brazil
ADAMA	Acadia Bio	Tebuconazole+Azoxystrobin	Soybean,wheat and corn	Launched in Argentina
Nippon Soda	Nae Fine Flowable	picarbutrazox	Rice	Registered in Japan
Nippon Soda	Pisi Rock Flowable	picarbutrazox	Vegetables	Registered in Japan
Valent U.S.A.	Elumin	Ethaboxam	Cucurbits	Registered in USA
PBI-Gordon	Kabuto SC	Isofetamid	Turf	Registered in USA
Iharabras S/A Indústrias Químicas	Fusão EC	Metominostrobin+Tebuconazole	Soybean	Launched in Brazil
Iharabras S/A Indústrias Químicas	Totalit	Chlorothalonil + Benthiavalicarb-isopropyl	Lettuce, potato, tomato, onion and grapes	Launched in Brazil
Stockton	REGEV	Melaleuca alternifolia extract +Difenoconazole	Vegetables and fruits	Registered in Guatemala
Insecticides
Syngenta	Voliam Targo	Abamectin+Chlorantraniliprole	Horticultural crops	Launched in Spain
	Force Evo	Tefluthrin	Corn	Registered in USA
	Proclaim 50	Emamectin benzoate	Soybean,cotton and beans	Registered in Brazil
	Minecto Pro	Cyantraniliprole+Abamectin	Vegetables	Registered in USA
BASF	Nomolt 150	Teflubenzuron	Apples	Launched in Brazil
Dow AgroSciences	Isoclast	Sulfoxaflor	Cereal and potato	Registered in Ireland
	Transform	Sulfoxaflor	Macadamia and avocado	Registered in Australia
	Spindle	Spinosad	Coffee, apple and grape	Registered in Brazil
Nufarm	Kaiso Sorbie	Lambda-cyhalothrin	Cotton	Registered in Brazil
ADAMA	Cormoran	Novaluron+Acetamiprid	Apple and pear	Launched in USA
UPL	Sperto	Acetamiprid+Bifenthrin	Soybean,corn and cotton	Launched in Brazil
UPL	Strafer MAX	Acetamiprid	Cotton	Launched in USA
Iharabras S/A Indústrias	Privilege	Acetamiprid+Pyriproxyfen	Soybean,kidney beans,cotton and tomato	Launched in Brazil
Iharabras S/A Indústrias	Eleitto	Acetamiprid+Ethofenprox	Vegetables and fruits	Launched in Brazil
Summit Agro USA	HARVANTA 50SL	CYCLAPRYN	fruiting vegetables, cucurbits, leafy vegetables and brassica vegetables	Registered in USA
CCAB Agro	Diafentiuron CCAB 500 SC	Diafenthiuron	Cotton,kidney beans and tomato	Registered in Brazil
Nematicides
Bayer CropScience	COPeO Prime	Fluopyram	Cotton	Launched in USA
ADAMA	Nimitz	Fluensulfone	Sweet potatoes, fruiting vegetables and melons	Registered in Japan,South Korea
Rotam	ReTurn XL	Oxamyl	Potato,cotton,tobacco and peanut	Registered in USA
SipcamRotam	ReTurn	Oxamyl	Vegetables and fruits	Launched in USA
Certis Europe	NEMguard DE	Garlic extract	Carrot	Registered in Netherlands
Seed treatments
Syngenta	Clariva Elite Beans	Pasteuria nishizawae PN1+Fluoxazolamine+ Fludioxonil+ Metalaxyl-M+ Thiamethoxam	Soybean	Registered in USA
	Fortenza	Cyantraniliprole	CornandCotton	Registered in USA
	PLENARIS	Oxathiapiprolin	Sunflower	Launched in USA
	Cruiser 600 FS	Thiamethoxam	Cotton,peanut,rice,sugarcane and soybean	Registered in Brazil
	Fortenza Duo	Cyantraniliprole+Thiamethoxam	Soybean,corn and cotton	Launched in Brazil
	Plenaris	Oxathiapiprolin	Sunflower	Launched in Argentina
Bayer CropScience	Routine FS	Isotianil	Rice	Launched in Japan
	Kirappu Seed FS	Ethiprole	Rice	Launched in Japan
	Scenic	Fluoxastrobin+Prothioconazole+Tebuconazole	Cereal	Launched in Chile
BASF	Stamina F4 Cereals	Fluxapyroxad+Pyraclostrobin	Cereal	Registered in USA
Arysta Life Science	Signal 300 ES	Cypermethrin	Wheat and barley	Launched in Ireland
Arysta Life Science	RANCONA V 100 PRO	Ipconazole+Carboxin	Soybean	Launched in North America
Nufarm	Maestro FS	Fipronil	Corn,soybean,rice,barley,kidney beans,wheat,peanut and cotton	Launched in Brazil
Nufarm	Saddler 350 SC	Thiodicarb	Corn and soybean	Launched in Brazil
Biopesticides ( will be released tomorrow )

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Pesticides Registered & Launched in 2017 and Analysis of Key Products

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2024 India Focus published!Magazine

2024 Latin America Focus published!Magazine

Call for Papers— 5th Ag Formulation & Application Technology Congress(FAT 2024) Event

Pesticides Registered & Launched in 2017 and Analysis of Key Products

Paul Zheng

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