Danforth to Collaborate With Dow AgroSciences to Employ EXZACT Precision Technology

Researchers working at the Donald Danforth Plant Science Center have entered into a research collaboration with Dow AgroSciences LLC, a wholly owned subsidiary of The Dow Chemical Company (NYSE: DOW), to study how its EXZACT™ Precision Technology can  help improve the root crop cassava for millions of people living in developing countries. 

Dow AgroSciences EXZACT™ Precision Technology provides a versatile and comprehensive toolkit for targeted genome modification in plants. Its demonstrated ability to specifically and efficiently add, edit or delete genes at targeted locations in plant genomes delivers a means for engineering multi-gene stacks, editing native genes and more efficiently producing crops with enhanced plant performance and value-added traits such as improved nutrition.

As part of the collaboration, researchers at the Danforth Center will generate data demonstrating the utility of what could be a key technology in its quest to improve nutritional value and virus resistance in farmer preferred varieties of the root crop cassava.  Dow AgroSciences is donating its technology to this effort and providing access to intellectual property, validated, high-quality zinc-finger reagents, and expertise through free consultation with Dow AgroSciences EXZACT™ Scientific Leader, Dr. Vipula Shukla.

Targeted transgene insertion and genome editing represents the future of plant biotechnology. This announcement comes on the heels of the Danforth Center’s recent success in completing the cassava genome sequence.

Cassava serves as the primary food source for more than 750 million people each day. While also an important source of local income for small farmers across much of Africa, Asia and Latin America, cassava production and use is limited by several constraints.  The starchy storage roots have poor nutritional content and the plant is susceptible to a number of pathogens. This is particularly the case in Africa, where one third of the continental harvest is lost each year to viral diseases; with Cassava Brown Streak Disease (CBSD) currently emerging as the major threat to food security in some parts of Eastern Africa.  Cassava Mosaic Disease (CMD) alone accounts for 35 million tons of yield loss in Africa, with an estimated value of nearly $1 billion per year.

About The Donald Danforth Plant Science Center
Founded in 1998, the Donald Danforth Plant Science Center is a not-for-profit research institute with a mission to improve the human condition through plant science. Research at the Danforth Center will feed the hungry and improve human health, preserve and renew the environment, and enhance the St. Louis region and Missouri as a world center for plant science.  Please visit www.danforthcenter.org  for additional information

About Dow AgroSciences
Dow AgroSciences LLC, based in Indianapolis, Indiana, USA, is a top-tier agricultural company that combines the power of science and technology with the "Human Element" to constantly improve what is essential to human progress. Dow AgroSciences provides innovative technologies for crop protection, pest and vegetation management, seeds, traits, and agricultural biotechnology to serve the world’s growing population. Global sales for Dow AgroSciences, a wholly owned subsidiary of The Dow Chemical Company, are $4.5 billion. Learn more at www.dowagro.com.